Body composition as a predictor of cognitive decline in the elderly: what is known so far
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Dementia
Cognitive decline
Body composition

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Body composition as a predictor of cognitive decline in the elderly: what is known so far. (2025). RIAGE - Revista Ibero-Americana De Gerontologia, 8(8), 341-353. https://doi.org/10.61415/riage.392

Resumo

Certain aspects of body composition can serve as predictors of cognitive impairment risk, enabling preventive interventions. Adipose tissue plays a complex role in cognitive health and dementia risk. This association appears to be influenced by age, sex and body fat distribution. However, factors like systemic inflammation and metabolic disturbances linked to obesity can negatively impact brain health. Muscle mass and strength are fundamental determinants of cognitive well-being. Interventions designed to increase muscle strength and to prevent muscular loss may hold promises for the maintenance of neurocognitive brain health, based on the role of myokines in pathophysiology and muscle-to-brain axis to healthy aging. Sarcopenia contributes to metabolic dysfunction, inflammation, and neuromuscular deterioration, potentially accelerating cognitive impairment. Sarcopenic obesity presents an elevated risk for adverse health outcomes, including cognitive decline and dementia. Maintaining an optimal balance between muscle and fat mass is crucial. Given these findings, promoting muscle health through resistance training and proper nutrition emerges as a key strategy in preventing cognitive impairment and fostering overall brain health.

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Referências

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